πŸ‡ΊπŸ‡Έ NGSS Β· Grades 6-8

MS-LS1-1: Living things are made of cells

MS-LS1-1 explained: investigating cells as the building blocks of life, living vs nonliving, misconceptions, a model answer and free practice questions.

NGSS performance expectation MS-LS1-1

Students who demonstrate understanding can: Conduct an investigation to provide evidence that living things are made of cells; either one cell or many different numbers and types of cells.

Clarification statement: Emphasis is on developing evidence that living things are made of cells, distinguishing between living and non-living things, and understanding that living things may be made of one cell or many and varied cells.

Grade band
Grades 6-8
Discipline
Life science
Topic
From Molecules to Organisms: Structures and Processes

Official wording from the Next Generation Science Standards (NGSS Lead States, 2013). NGSS is a registered trademark of WestEd. Neither WestEd nor the lead states and partners that developed the NGSS were involved in the production of this page, and they do not endorse it. View on nextgenscience.org

What MS-LS1-1 means

Every organism on Earth, from a bacterium to a blue whale, is built from cells. Middle schoolers are expected to gather that evidence for themselves rather than simply being told it. They look at onion skin, cheek cells, pond water and plant leaves under a microscope, and they notice that every living sample is made of small, bounded units, while samples such as sand, cotton thread or a crystal of salt are not.

The investigation should lead students to two conclusions. First, cells are a defining feature of life: anything alive is made of at least one cell. Second, organisms differ in how many cells they have and what kinds. A paramecium or a yeast cell is a complete organism on its own, while a human body contains trillions of cells of many specialized types, such as nerve, muscle and blood cells.

Students also practice the skills of a careful investigation: preparing a slide, focusing from low to high power, drawing what they actually see, and recording magnification. The goal is evidence-based reasoning, so a strong answer ties each claim to an observation.

Students should be able to

  • Prepare and observe slides of living and nonliving materials and record accurate drawings with the magnification used.
  • Use microscope observations as evidence that living things are made of one or more cells.
  • Distinguish unicellular organisms from multicellular organisms and give an example of each.
  • Explain why a sample of a nonliving material such as salt or sand does not show a cellular structure.
  • Describe how a multicellular organism contains many different types of cells.

Common misconceptions

Thinking cells are only found in animals

Some students picture cells as a body-only idea. Showing onion skin, a leaf and mold side by side makes it clear that plants and fungi are made of cells too.

Believing single cells are not really alive

Students may think an organism has to be large or have organs to count as alive. A moving, feeding paramecium under the microscope is strong evidence that one cell can carry out every life function.

Assuming anything that came from a living thing is still made of living cells

Cotton, paper and cooked food came from organisms, yet their cells are dead or broken down. Discuss the difference between being made of cells and being alive right now.

Confusing bigger organisms with bigger cells

An elephant is larger than a mouse because it has many more cells, not because its cells are giant. Most animal cells are similar in size whatever the size of the animal.

Model answer: is the mystery sample alive?

A student views three samples under a microscope at 100x. Sample A shows many small boxes with dark dots inside. Sample B shows sharp-edged cubes with no inner structure. Sample C shows one oval shape that moves and has hair-like structures around its edge. Which samples are or were living, and what is the evidence?

  1. Claim: Samples A and C come from living things, and Sample B does not.
  2. Evidence for A: it is made of many repeating units, each with a boundary and a dark structure inside, which matches what cells look like. It is multicellular, like plant tissue.
  3. Evidence for C: it is a single bounded unit that moves on its own, so it is a unicellular organism.
  4. Evidence for B: the cubes have no boundary-and-contents structure; they look like crystals such as salt, which are not made of cells.
  5. Reasoning: all living things are made of one or more cells, so only samples with a cellular structure can be living.

Answer: A (multicellular) and C (unicellular) are from living things because they are made of cells; B is a nonliving crystal with no cells.

Teaching MS-LS1-1

Run this as a genuine investigation: give groups a mixed set of labeled and unlabeled slides and ask them to sort living from nonliving before revealing the answers. Insist on drawings that show only what is visible, with the total magnification written next to each. Comparing a prepared slide of a multicellular leaf with a drop of pond water sets up the unicellular versus multicellular discussion naturally.

Assessment items usually present microscope images or data tables and ask students to use them as evidence, so practice writing claim, evidence and reasoning sentences from images rather than recalling vocabulary alone.

6 practice questions

Original questions written for this standard. Choose an option or type your answer, then press Check. Every question has a worked explanation.

Score: 0 / 6(0 of 6 checked)
  1. 1.

    Which observation is the best evidence that a sample comes from a living thing?

    Question 1 options
    Answer and explanation

    Answer: B) It is made of one or more cells

    Being made of cells is a feature of all living things. Color, texture and dissolving do not tell living from nonliving.

  2. 2.

    A paramecium is made of one cell. What does this tell you about it?

    Question 2 options
    Answer and explanation

    Answer: C) It is a unicellular organism that carries out all life functions in one cell

    A unicellular organism is a complete living thing made of a single cell, which takes in food, gets rid of waste and reproduces.

  3. 3.

    What word describes an organism made of many cells?

    Answer and explanation

    Answer: multicellular (also accepted: multi-cellular)

    Multicellular organisms, such as humans and oak trees, are made of many cells, often of many different types.

  4. 4.

    Under a microscope, grains of table salt look like tiny cubes with no inner parts. What should a student conclude?

    Question 4 options
    Answer and explanation

    Answer: A) Salt is not made of cells, so it is not a living thing

    Salt is a crystal. It has no cell boundary or contents, which fits a nonliving material.

  5. 5.

    Why does a human body contain many different kinds of cells, such as nerve and muscle cells?

    Question 5 options
    Answer and explanation

    Answer: B) Different cells do different jobs in a multicellular organism

    In multicellular organisms, cells are specialized: nerve cells carry signals and muscle cells contract.

  6. 6.

    What tool do scientists use to see cells that are too small to see with the eye alone?

    Answer and explanation

    Answer: microscope (also accepted: a microscope, light microscope)

    Most cells are far too small to see without magnification, so a microscope is needed.

Builds on

  • 4-LS1-1
  • 1-LS1-1

Leads to

Teach MS-LS1-1

Make a lesson on MS-LS1-1

A full lesson with slides, activities and an exit ticket on living things are made of cells, pitched to grades 6-8 and editable in PowerPoint or Google Slides.

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Make a worksheet

A printable, differentiated worksheet on MS-LS1-1 with an answer key, ready in about a minute.

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Build a self-marking test

Turn living things are made of cells into a quiz students answer online that marks itself, with a class summary for you.

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FAQ

What do students do for MS-LS1-1?

They conduct an investigation, usually with microscopes, to collect evidence that living things are made of cells, comparing living and nonliving samples and unicellular and multicellular organisms.

Do students need to name organelles for MS-LS1-1?

No. The focus is evidence that organisms are made of cells. The functions of cell parts belong to MS-LS1-2.

More life science standards

MS-LS1-2: How cell parts work togetherMS-LS1-3: Body systems working togetherMS-LS1-4: Behaviors and structures that aid reproductionMS-LS1-5: Genes, environment and growthMS-LS1-6: Photosynthesis, matter and energyMS-LS1-7: Food, new molecules and energy releaseMS-LS1-8: Senses, signals and memoryMS-LS2-1: Resources and populationsMS-LS2-2: Patterns of interaction in ecosystemsMS-LS2-3: Matter cycles and energy flows in ecosystems
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